A rare cause of dysphagia: compression of the esophagus by an anterior cervical osteophyte due to ankylosing spondylitis
İlknur Albayrak, Sinan Bağcacı, Ali Sallı, Sami Kucuksen, Hatice Uğurlu
Korean J Intern Med. 2013;28(5):614-618. Published online August 14, 2013
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatological disease affecting the axial skeleton with various extra-articular complications. Dysphagia due to a giant anterior osteophyte of the cervical spine in AS is extremely rare. We present a 48-year-old male with AS suffering from p..
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Pulmonology
The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer
Kyoung Ju Lee, Eun Joo Lee, Gyu Young Hur, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo, Sung Yong Lee
Korean J Intern Med. 2013;28(4):449-455. Published online July 1, 2013
Background/AimsChemotherapy combined with radiation therapy is the standard treatment for limited stage small cell lung cancer (LS-SCLC). Although numerous studies indicate that the overall duration of chemoradiotherapy is the most relevant predictor of outcome, the optimal ch..
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Gastroenterology
Recent trends in hepatitis B virus infection in the general Korean population
Hyuck Kim, A Ri Shin, Hoe Hoon Chung, Min Kyoung Kim, Ji Sung Lee, Jae-Jun Shim, Byung-Ho Kim
Korean J Intern Med. 2013;28(4):413-419. Published online July 1, 2013
Background/AimsHepatitis B virus (HBV) is the major cause of chronic liver disease in Korea, but viral prevalence has decreased because of hepatitis B vaccination programs. In this study, we investigated longitudinal changes in HBV in fection in the general Korean population.<..
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Hemato-oncology
Third-line docetaxel chemotherapy for recurrent and metastatic gastric cancer
Ji Hyun Lee, Sung-Hyun Kim, Sung Yong Oh, Suee Lee, Hojin Lee, Hye Jung Lee, Hyo-Jin Kim
Korean J Intern Med. 2013;28(3):314-321. Published online May 1, 2013
Background/AimsTo determine the efficacy and toxicity of docetaxel as a third-line therapy for patients with relapsed gastric cancer who have undergone modified oxaliplatin-fluorouracil (m-FOLFOX)-4 and modified irinotecan-fluorouracil (m-FOLFIRI) regimens.
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Molecular targeted therapy for advanced gastric cancer
Jong Gwang Kim
Korean J Intern Med. 2013;28(2):149-155. Published online February 27, 2013
Although medical treatment has been shown to improve quality of life and prolong survival, no significant progress has been made in the treatment of advanced gastric cancer (AGC) within the last two decades. Thus, the optimum standard first-line chemotherapy regimen for AGC remains debatable, and..
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Gastroenterology
Can postendoscopic retrograde cholangiopancreatography pancreatitis be prevented by a pharmacological approach?
Young Koog Cheon
Korean J Intern Med. 2013;28(2):141-148. Published online February 27, 2013
Acute pancreatitis remains the most frequent complication of endoscopic retrograde cholangiopancreatography (ERCP), with reported incidence rates that have changed little over several decades. Patient- and procedure-related risk factors for post-ERCP pancreatitis (PEP) are well-defined. Effective..
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Endoscopic drainage in patients with inoperable hilar cholangiocarcinoma
Ye Jin Park, Dae Hwan Kang
Korean J Intern Med. 2013;28(1):8-18. Published online December 28, 2012
Hilar cholangiocarcinoma has an extremely poor prognosis and is usually diagnosed at an advanced stage. Palliative management plays an important role in the treatment of patients with inoperable hilar cholangiocarcinoma. Surgical, percutaneous, and endoscopic biliary drainage are three modalities..
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Characteristics of Subjects with Very Low Serum Low-Density Lipoprotein Cholesterol and the Risk for Intracerebral Hemorrhage
Jae-Geun Lee, Sung Joo Koh, So Yeon Yoo, Jung Re Yu, Sang Ah Lee, Gwanpyo Koh, Daeho Lee
Korean J Intern Med. 2012;27(3):317-326. Published online September 1, 2012
Background/AimsThe clinical implications of hypocholesterolemia have not been well studied, although some studies have revealed an association between hypocholesterolemia and intracerebral hemorrhage (ICH). We evaluated the clinical characteristics of subjects with very low-de..
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Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
Hyeon Young Yoon, Young Koog Cheon, Hye Jin Choi, Chan Sup Shim
Korean J Intern Med. 2012;27(3):278-284. Published online September 1, 2012
Background/AimsThe aim of this non-randomized study was to determine the role of photodynamic therapy (PDT) in a multimodal approach for the palliation of advanced esophageal carcinoma. MethodsTwenty consecutive patients with obstructing esophag..
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Bacterial Yield from Quantitative Cultures of Bronchoalveolar Lavage Fluid in Patients with Pneumonia on Antimicrobial Therapy
Eun Sun Kim, Eui-Chong Kim, Sang-Min Lee, Seok-Chul Yang, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Jae-Joon Yim
Korean J Intern Med. 2012;27(2):156-162. Published online May 31, 2012
Background/AimsEarly diagnosis and appropriate antimicrobial choice are crucial when managing pneumonia patients, and quantitative culture of bronchoalveolar lavage (BAL) fluid is considered a useful method for identifying pneumonia pathogens. We evaluated the quantitative yie..
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Transcatheter Arterial Embolization as Treatment for a Life-Threatening Retroperitoneal Hemorrhage Complicating Heparin Therapy
Sang-Ho Park, Se-Whan Lee, Ung Jeon, Min-Hyeok Jeon, Seung-Jin Lee, Won-Yong Shin, Dong-Kyu Jin
Korean J Intern Med. 2011;26(3):352-355. Published online September 13, 2011
Spontaneous retroperitoneal hemorrhage is a distinct clinical entity that can present in the absence of specific underlying pathology or trauma and is typically associated with anticoagulation therapy. We report a case of a 74-year-old female patient with a cerebral infarction related to atrial f..
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Acute Lymphoblastic Leukemia in Elderly Patients: A Single Institution's Experience
Dong-Yeop Shin, Inho Kim, Ki-Hwan Kim, Younak Choi, Seung Hoon Beom, Yaewon Yang, Yoojoo Lim, Eunyoung Lee, June Koo Lee, Ji Yeon Kim, Hyun Kyung Kim, Sung-Soo Yoon, Dong Soon Lee, Seonyang Park, Byoung-Kook Kim
Korean J Intern Med. 2011;26(3):328-339. Published online September 13, 2011
Background/AimsWe investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL). MethodsWe reviewed the clinical data, laboratory findings, bone marrow findings, and cytogenetic analysis of el..
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Molecular Epidemiology of Hepatitis B Virus
Jia-Horng Kao
Korean J Intern Med. 2011;26(3):255-261. Published online September 13, 2011
Although safe and effective vaccines for hepatitis B virus (HBV) have been available for nearly three decades, this virus kills at least 600,000 people annually worldwide and remains the leading global cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Because the HBV reverse tr..
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Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
Alfredo Ceballos, Gladys Castaño, Sarahí Mendoza, Juan González, Rosa Mas, Lilia Fernández, José Illnait, Meilis Mesa, Rafael Gámez, Julio César Fernández, Ricardo Telles, Duany Marrero, Mainel Gómez Eng, Dalmer Ruiz, Yunaisi Jardines
Korean J Intern Med. 2011;26(2):168-178. Published online June 1, 2011
Background/AimsIncreased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight ..
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Serum Globotriaosylceramide Assay as a Screening Test for Fabry Disease in Patients with ESRD on Maintenance Dialysis in Korea
Jeong-Yup Kim, Young-Youl Hyun, Ji-Eun Lee, Hye-Ran Yoon, Gu-Hwan Kim, Han-Wook Yoo, Seong-Tae Cho, No-Won Chun, Byoung-Chunn Jeoung, Hwa-Jung Kim, Keong-Wook Kim, Seong-Nam Kim, Yung-A Kim, Hyun-Ah Lee, Jong-Young Lee, Yung-Chun Lee, Hun-Kwan Lim, Keong-Sik Oh, Seong-Hwan Son, Beong-Hee Yu, Kyeong-So Wee, Eun-Jong Lee, Young-Ki Lee, Jung-Woo Noh, Seung-Jung Kim, Kyu-Bok Choi, Suk-Hee Yu, Heui-Jung Pyo, Young-Joo Kwon
Korean J Intern Med. 2010;25(4):415-421. Published online November 27, 2010
Background/AimsFabry disease is an X-linked recessive and progressive disease caused by α-galactosidase A (α-GaL A) deficiency. We sought to assess the prevalence of unrecognized Fabry disease in dialysis-dependent patients and the efficacy of serum globotriaosylceramide (GL..
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The Role of Photodynamic Therapy for Hilar Cholangiocarcinoma
Young Koog Cheon
Korean J Intern Med. 2010;25(4):345-352. Published online November 27, 2010
The prognosis for hilar cholangiocarcinoma is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses results in median survival times of 4-6 months for advanced bile duct cancer. Photodyn..
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Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
Hae-Rim Kim, Mi-Kyung Park, Mi-La Cho, Kyoung-Woon Kim, Hye-Joa Oh, Jin-Sil Park, Yang-Mi Heo, Sang-Heon Lee, Ho-Youn Kim, Sung-Hwan Park
Korean J Intern Med. 2010;25(3):317-326. Published online August 31, 2010
Background/AimsThis study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. MethodsHuman RA synovial fibr..
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Left Ventricular Dyssynchrony in Patients Showing Diastolic Dysfunction without Overt Symptoms of Heart Failure
Jae Hoon Kim, Hee Sang Jang, Byung Seok Bae, Seung Min Shin, Ki Ju Kim, Jung Gil Park, Hyun Jae Kang, Bong Ryeol Lee, Byung Chun Jung
Korean J Intern Med. 2010;25(3):246-252. Published online August 31, 2010
Background/AimsFew studies have assessed left ventricular (LV) dyssynchrony in cases of diastolic dysfunction that do not include overt symptoms of heart failure. We hypothesized that systolic or diastolic dyssynchrony involves unique features with respect to the degree of dia..
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The Current Practice of Skin Testing for Antibiotics in Korean Hospitals
So Hee Lee, Heung Woo Park, Sae Hoon Kim, Yoon Seok Chang, Sun Sin Kim, Sang Heon Cho, Kyung Up Min, You Young Kim
Korean J Intern Med. 2010;25(2):207-212. Published online June 1, 2010
Background/AimsAntibiotic skin testing is a useful procedure for identifying patients with IgE-mediated hypersensitivity to antibiotics. The procedures, however, have not been standardized, and the testing is performed with diverse protocols in Korean hospitals wards. Thus, we..
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The Contribution of Abdominal Obesity and Dyslipidemia to Metabolic Syndrome in Psychiatric Patients
Sung-Hwan Kim, Kiwon Kim, Mi Hyang Kwak, Hak Jin Kim, Hong-Sup Kim, Ki Hoon Han
Korean J Intern Med. 2010;25(2):168-173. Published online June 1, 2010
Background/AimsMetabolic syndrome is an emerging risk factor for cardiovascular disease. This study investigated the prevalence of metabolic syndrome among psychiatric patients in order to identify the dominant factors of metabolic syndrome. Methods
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